Volume 1 Issue 2
Recurrent Osteogenesis Imperfecta
Amber N Mullins* and Howard E Herrell
Osteogenesis Imperfecta (OI) is a group of inherited disorders characterized by bone fragility. The perinatal lethal form of the disease, type II, has three different mechanisms of inheritance: new dominant mutations, parental germline mosaicism, and autosomal recessive inheritance.
Locally Advanced Cervical Carcinoma Treated with Uterine Artery Embolization and Concurrent Chemoradiotherapy
Yorito Yamamoto M.D*
Patients with locally advanced disease (stages I B2-IV A) are at high risk for recurrence and account for the majority of cervical cancer deaths. An initiative to improve treatment outcomes of locally advanced cervical cancer culminated in when the National Cancer Institute issued a statement that cisplatin-based chemotherapy in combination with radiotherapy represented the new standard of care.
Atrophic Vaginitis in Breast Cancer Survivors: A Difficult Survivorship Issue
Joanne L. Lester*, PhD, CNP, AOCN, Gaurav Pahouja, Barbara L. Andersen, PhD, Maryam B. Lustberg, MD, MPH
Management of breast cancer includes systematic therapies including chemotherapy and endocrine therapy, can lead to a variety of symptoms that can impair the quality of life of many breast cancer survivors. Atrophic vaginitis, caused by decreased levels of circulating estrogen to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced ovarian failure and endocrine therapies including aromatase inhibitors and selective estrogen receptor modulators can trigger the onset of atrophic vaginitis or exacerbate existing symptoms.